Senior Scientist, Chemical Biology - La Jolla, California
Org Marketing Statement
Pfizer Inc: Working together for a healthier world
Founded in 1849, Pfizer is the world's premier biopharmaceutical company taking new approaches to better health. We discover, develop, manufacture and deliver quality, safe and effective prescription medicines to treat and help prevent disease for both people and animals. We also partner with healthcare providers, governments and local communities around the world to expand access to our medicines and to provide better quality health care and health system support. At Pfizer, colleagues in more than 90 countries work every day to help people stay happier and healthier longer and to reduce the human and economic burden of disease worldwide.
Responsibilities
Position Purpose:
Develop and implement chemical biology techniques to advance projects across the Oncology portfolio, primarily through the design and application of chemical probes in complex biological systems.
Primary Duties:
- Design and carry out experiments with functional chemical probes to address specific project needs across the Oncology Research Unit (ORU).
- Work in collaboration with ORU biology to design and execute experiments aimed at answering key biological questions.
- Work in collaboration with the Worldwide Medicinal Chemistry Design and Synthesis groups to conceive and prepare chemical probes.
- Apply and/or develop affinity/activity-based proteomic probes to profile the functional state of enzyme targets in native biological systems and assess selectivity and/or safety of compounds.
- Design of photoaffinity probes and conduct photoaffinity labeling experiments for covalent capture of targets.
- Build effective partnerships with the biophysics group in the ORU and the MS proteomics group in Worldwide Medicinal Chemistry.
- Expand the global chemical proteomics toolbox. Where applicable, use click chemistries to build functional molecules in situ.
- Use chemical proteomics to elucidate biological targets of active molecules from phenotypic screens to expedite drug discovery.
- Design and application of fluorescent probes for live cell imaging studies.
Qualifications
Educational Qualifications:
Doctoral level degree or equivalent experience in chemical biology or related area
Training and Experience:
- Strong track record of delivering biological insights through chemical biology experimentation.
- Highly skilled synthetic chemist with comprehensive knowledge of building chemical biology probes.
- Highly skilled laboratory experimentalist with experience of working on biological systems (cells/cell lysates/ex vivo tissues etc).
- Experience with standard methods used in chemical biology including: protein purification/enrichment, chromatography (size exclusion, ion exchange, affinity) immunoprecipitation, gel electrophoresis; Western blotting.
Preferred:
- Post doctorate in chemical biology or related area.
- Target identification and mechanism of action elucidation experience.
- Comfortable interpreting MS data for identification of target proteins.
- Experience working in the following areas would be desirable: Click chemistry; photoaffinity cross-linking; in-gel fluorescence; chemical modification of proteins; protein engineering; mammalian tissue culture, SILAC methodology; siRNA for target validation.
Equal Employment Opportunity
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Pfizer in the U.S. In certain circumstances it may be advantageous to Pfizer to support the application(s) for temporary visa classification and/or sponsor applications for permanent residence so that a foreign national colleague can accept or remain in a work assignment in the U. S. For certain classes of temporary visas, the resulting work authorization may be specific to Pfizer and the specific job and/or work site. Pfizer may at its business discretion decide to or refrain from obtaining, maintaining and/or extending the temporary visa status and/or sponsoring a colleague for permanent residency and /or employment eligibility, considering factors such as availability of qualified U.S. workers and the colleague's long-term prospects for securing lawful permanent residence, among other reasons. Employment applicants requiring immigration sponsorship must disclose, when initial application for employment is made, whether or not they are legally authorized to work for Pfizer in the U.S. and, if so, whether that authorization permits them to work in the job they seek. In no case should Pfizer's support of a colleague's temporary visa application or sponsorship of a colleague for permanent residence be construed to guarantee success of that application or amend or otherwise invalidate the "at-will" employment relationship between the colleague and Pfizer.
Pfizer Inc: Working together for a healthier world
Founded in 1849, Pfizer is the world's premier biopharmaceutical company taking new approaches to better health. We discover, develop, manufacture and deliver quality, safe and effective prescription medicines to treat and help prevent disease for both people and animals. We also partner with healthcare providers, governments and local communities around the world to expand access to our medicines and to provide better quality health care and health system support. At Pfizer, colleagues in more than 90 countries work every day to help people stay happier and healthier longer and to reduce the human and economic burden of disease worldwide.
Responsibilities
Position Purpose:
Develop and implement chemical biology techniques to advance projects across the Oncology portfolio, primarily through the design and application of chemical probes in complex biological systems.
Primary Duties:
- Design and carry out experiments with functional chemical probes to address specific project needs across the Oncology Research Unit (ORU).
- Work in collaboration with ORU biology to design and execute experiments aimed at answering key biological questions.
- Work in collaboration with the Worldwide Medicinal Chemistry Design and Synthesis groups to conceive and prepare chemical probes.
- Apply and/or develop affinity/activity-based proteomic probes to profile the functional state of enzyme targets in native biological systems and assess selectivity and/or safety of compounds.
- Design of photoaffinity probes and conduct photoaffinity labeling experiments for covalent capture of targets.
- Build effective partnerships with the biophysics group in the ORU and the MS proteomics group in Worldwide Medicinal Chemistry.
- Expand the global chemical proteomics toolbox. Where applicable, use click chemistries to build functional molecules in situ.
- Use chemical proteomics to elucidate biological targets of active molecules from phenotypic screens to expedite drug discovery.
- Design and application of fluorescent probes for live cell imaging studies.
Qualifications
Educational Qualifications:
Doctoral level degree or equivalent experience in chemical biology or related area
Training and Experience:
- Strong track record of delivering biological insights through chemical biology experimentation.
- Highly skilled synthetic chemist with comprehensive knowledge of building chemical biology probes.
- Highly skilled laboratory experimentalist with experience of working on biological systems (cells/cell lysates/ex vivo tissues etc).
- Experience with standard methods used in chemical biology including: protein purification/enrichment, chromatography (size exclusion, ion exchange, affinity) immunoprecipitation, gel electrophoresis; Western blotting.
Preferred:
- Post doctorate in chemical biology or related area.
- Target identification and mechanism of action elucidation experience.
- Comfortable interpreting MS data for identification of target proteins.
- Experience working in the following areas would be desirable: Click chemistry; photoaffinity cross-linking; in-gel fluorescence; chemical modification of proteins; protein engineering; mammalian tissue culture, SILAC methodology; siRNA for target validation.
Equal Employment Opportunity
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Pfizer in the U.S. In certain circumstances it may be advantageous to Pfizer to support the application(s) for temporary visa classification and/or sponsor applications for permanent residence so that a foreign national colleague can accept or remain in a work assignment in the U. S. For certain classes of temporary visas, the resulting work authorization may be specific to Pfizer and the specific job and/or work site. Pfizer may at its business discretion decide to or refrain from obtaining, maintaining and/or extending the temporary visa status and/or sponsoring a colleague for permanent residency and /or employment eligibility, considering factors such as availability of qualified U.S. workers and the colleague's long-term prospects for securing lawful permanent residence, among other reasons. Employment applicants requiring immigration sponsorship must disclose, when initial application for employment is made, whether or not they are legally authorized to work for Pfizer in the U.S. and, if so, whether that authorization permits them to work in the job they seek. In no case should Pfizer's support of a colleague's temporary visa application or sponsorship of a colleague for permanent residence be construed to guarantee success of that application or amend or otherwise invalidate the "at-will" employment relationship between the colleague and Pfizer.
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